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The Prime®

Caralluma fimbriata fights against Leptin Resistance

Caralluma fimbriata
Caralluma Fimbriata is an edible, succulent cactus native to India. For centuries, it has been eaten in rural India, raw, in dishes, or preserved in chutneys and pickles. Due to its purported ability to suppress hunger and enhance stamina, it has been used by tribe hunters as a portable food and thirst quencher, hence it is commonly considered a ‘famine food’.

Not all Caralluma fimbriata extracts are created equal. Caralluma works best when it has high and standardised concentration of pregnane glycoside, via a patented process developed by Dr. Rajendran (US patent: 7,976,880).

A standardized and proprietary extract Caralluma Fimbriata containing controlled levels of pregnane glycosides.

1. Increases lipolysis

Improves Leptin sensitivity and reduces Ghrelin to inhibit the hunger sensor of the hypothalamus and suppress appetite. These results in negative energy balance, which forces the body to burn the fat and increase ATP.

2. Inhibits fat synthesis (lipogenesis)

Blocks the formation of acetyl coenzyme A (ACA) and malonyl coenzyme A (MCA), which are the building blocks of fat.

3. Reduces adipocyte size and numbers

Inhibits the differentiation of pre-adipocytes into adipocytes (new fat cells), thereby reducing the formation of new adipose tissue and consequently reducing the amount of fat formation.

Study Results
An eight-week double-blind, randomized placebo-controlled clinical trial was conducted on 50 overweight adult men and women (25-60 years). They received 1 g of Caralluma Fimbriata extract per day.
    The study showed clinically significant results for:
  • Waist circumference (reflective of intraabdominal fat)*
  • Appetite suppression which lead to:
    – Healthier food choices*
    – Reduced caloric consumption per day*
  • when combined with a healthy diet and exercise.

A 12-week randomized, placebo-controlled study was conducted on 43 obese and overweight adult men and women (29-59 years). They received 1 g of Caralluma fimbriata extract per day.
    The study showed statistically significant results for:
  • Waist circumference (positively correlated with a reduction in abdominal fat)*
  • Waist-to-hip ratio decline*
  • Significant decline in palatability of test meal and reduced sodium intake*
  • when combined with a healthy diet and exercise.

View Clinical Research done on Caralluma Fimbriata

Take 1 capsule twice daily half an hour before meals.

Active Ingredients
Caralluma fimbriata extract (Aerial parts)495mg
Capsule Sample
Pack Size
30s; 60s